Complementary Effects of Two Growth Factors in Multifunctionalized Silk Nanofibers for Nerve Reconstruction.

Kaplan, David, 1953-
Dinis, Tony M.
Vidal, Guillaume.
Jose, Rodrigo R.
Vigneron, Pascale.
Fitzpatrick, Vincent.
Marin, Frédéric.
Egles, Christophe.

With the aim of forming bioactive guides for peripheral nerve regeneration, silk fibroin was electrospun to obtain aligned nanofibers. These fibers were functionalized by incorporating Nerve Growth Factor (NGF) and Ciliary NeuroTrophic Factor (CNTF) during electrospinning. PC12 cells grown on the fibers confirmed the bioavailability and bioactivity of the NGF, which was not significantly released ... read more

Biomedical materials.
Nervous system--Regeneration.
Nanostructured materials.
Tufts University. Department of Biomedical Engineering.
Permanent URL
Original publication
Dinis, T. M., G. Vidal, R. R. Jose, P. Vigneron, D. Bresson, V. Fitzpatrick, F. Marin, D. L. Kaplan and C. Egles (2014). "Complementary effects of two growth factors in multifunctionalized silk nanofibers for nerve reconstruction." PLoS ONE 9(10). doi: 10.1371/journal.pone.0109770.
ID: tufts:17844
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