BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice.

Kim, WonHee.
Ma, Liang.
Lomoio, Selene.
Willen, Rachel.
Lombardo, Sylvia.
Dong, Jinghui.
Haydon, Philip G.
Tesco, Giuseppina.

Background: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer's disease (AD) patients. Our previous studies have shown that the clathrin adaptor Golgi-localized γ-ear-containing ARF binding protein 3 (GGA3) plays a key role in the trafficking of BACE1 to lysoso... read more

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