Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β.

Miyazawa, Taiki.
Nakagawa, Kiyotaka.
Kim, Sharon H.
Thomas, Michael J.
Paul, Ligi.
Zingg, Jean-Marc.
Dolnikowski, Gregory G.
Roberts, Susan B.
Kimura, Fumiko.
Miyazawa, Teruo.
Azzi, Angelo.
Meydani, Mohsen.

Background: Dietary bioactive compounds capable of improving metabolic profiles would be of great value, especially for overweight individuals undergoing a caloric restriction (CR) regimen. Curcumin (Cur), a possible anti-obesity compound, and piperine (Pip), a plausible enhancer of Cur's bioavailability and efficacy, may be candidate agents for controlling body fat, metabolism and low grade infla... read more

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