Detangling PPI networks to uncover functionally meaningful clusters.

Hall-Swan, Sarah.
Crawford, Jake.
Newman, Rebecca.
Cowen, Lenore J.

Background: Decomposing a protein-protein interaction network (PPI network) into non-overlapping clusters or communities, sometimes called "network modules," is an important way to explore functional roles of sets of genes. When the method to accomplish this decomposition is solely based on purely graph-theoretic measures of the interconnection structure of the network, this is often called unsupe... read more

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