Characterization of MCF-12A cell phenotype, response to estrogens, and growth in 3D.

Sweeney, Michael F.
Sonnenschein, Carlos.
Soto, Ana M.

Background: Three-dimensional cultures of mammary epithelial cells allow for biologically-relevant studies of the development of the mammary gland in rodents and humans under normal and pathological conditions, like carcinogenesis. Under these conditions, mammotropic hormones play significant roles in tissue morphogenesis. Therefore, a system that recreates the normal, hormonally responsive epithe... read more

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