The Role of TRF4 in the Maintenance of CAG Repeats in Yeast.

Verra, Lauren N.

Trinucleotide repeats are repetitive sequences in the genome prone to both fragility and instability. The Saccharomyces cerevisiae gene TRF4 may function in DNA repair or cohesion mechanisms, in addition to an RNA-level role leading to the degradation of aberrant RNAs. This study shows that Δtrf4 displays increased fragility and instability in CAG repeat tracts over wild-type yeast, suggesting a r... read more

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Undergraduate Honors Theses
Tufts University. Department of Biology.
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